神经生理、心血管病理生理研究中，经常需要采集、记录、分析生物电信号，观察离体组织或是细胞中电活动的变化。美国RedShirtImaging专注于高速成像技术，通过专业软件对采集的生物电信号进行分析处理，不仅可以获得电信号变化的时间，还可以获得电信号的空间分布以及传播规律。使用图像分析法记录生物电信号的变化，结合高速成像技术与压敏（或钙敏）染料采集、分析、生物电信号，使用各种专用摄像头结合软件能将电信号记录下来并经过各种处理编辑成波形曲线，得到伪彩图象和动态图像等，进一步进行各种复杂分析。是生理学、神经生理学、心血管病理生理学研究不可或缺的工具。

• 图像法采集、记录、分析生物电信号

• 不直接接触组织或细胞，没有机械刺激及破坏

• 精确度高、减小人为误差

Piao HH, Rajakumar D, Kang BE, Kim EH, Baker BJ. (2015) Combinatorial Mutagenesis of the Voltage-Sensing Domain Enables the Optical Resolution of Action Potentials Firing at 60 Hz by a Genetically Encoded Fluorescent Sensor of Membrane Potential. J Neurosci. 35(1):372-85.

Wright NJ, Sides LJ, Walling K. (2015) Initial studies on the direct and modulatory effects of nitric oxide on an identified central Helix aspersa neuron. Invert Neurosci. 15(1):175.

Sedmera D, Reckova M, Rosengarten C, Torres MI, Gourdie RG, Thompson RP. (2015) Optical Mapping of Electrical Activation in the Developing Heart. Microscopy and Microanalysis 11(3): 209-215.

Qian T, Chen R, Nakamura M, Furukawa T, Kumada T, Akita T, Kilb W, Luhmann HJ, Nakahara D, Fukuda A. (2014) Activity-dependent endogenous taurine release facilitates excitatory neurotransmission in the neocortical marginal zone of neonatal rats. Front Cell Neurosci. Feb 10;8:33.

Malyshev AY, Balaban PM (2014) Changes in Intracellular Calcium Ion Concentrations during Generation of High-Amplitude EPSP in Neurons in the Common Snail Neurosci Behav Physiol

Weigel S, Flisikowska T, Schnieke A, Luksch H. (2014) Hybrid voltage sensor imaging of eGFP-F expressing neurons in chicken midbrain slices. J Neurosci Methods. 233C:28-33.

Popovic MA, Gao X, Carnevale NT, Zecevic D. (2014) Cortical Dendritic Spine Heads Are Not Electrically Isolated by the Spine Neck from Membrane Potential Signals in Parent Dendrites. Cereb. Cortex 24 (2): 385-395.

Cantu D, Walker K, Andresen L, Taylor-Weiner A, Hampton D, Tesco G, Dulla CG. (2014) Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control. Cereb. Cortex.