光遗传学(optogenetics)——结合遗传工程与光来操纵个别神经细胞的活性。这方法有助于发展一系列脑相关失调的新疗法。
Teleopto无线光遗传学刺激器由耦合了高精度LED光源的无线光导纤维,远程控制器,接收器及相关配件组成。
高精度LED光源的光导纤维是高亮度的LED灯源和光导纤维耦合而成,实现输出功率达到mW级。应用这个技术可以获取高精度的LED光源。所需光源颜色不同,选择不同的光导纤维。
无线光遗传学刺激器突破了传统的有线刺激,解放了动物,使其不再受到连接线带来的束缚,动物可以自由活动,使其处于更自然的状态下,有利于实验获取精准的数据。
实验动物自由活动,不受束缚
通过红外遥控操作
适用于大鼠和小鼠
接收器体积微小且轻便
兼容性强
光源精度高,稳定
多种光源颜色可选
Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction.
Roger Marek, Li Xu, Robert K. P. Sullivan, Pankaj Sah
Nature Neuroscience (2018) 21(5):654-658. DOI: 10.1038
Top-down cortical input during NREM sleep consolidates perceptual memory.
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Htr2a-Expressing Cells in the Central Amygdala Control the Hierarchy between Innate and Learned Fear.
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Cell (2015) 163(5):1153-64
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Neuron (2015) 86:1304-16
The lateral parabrachial nucleus is actively involved in the acquisition of fear memory in mice.
Sato M, Ito M, Nagase M, Sugimura YK, Takahashi Y, Watabe AM, Kato F
Molecular Brain (2015) 8:22