Background
Diabetes, obesity and other metabolic diseases are chronic diseases caused by multiple factors such as genetics and environment. In real life, the imbalance between energy intake and consumption accelerates the increase of obesity and metabolic syndrome worldwide, posing a severe threat to human life and health.
With people's concern about the balance between health, life span and aging process, researches on the pathogenesis, prevention and treatment of metabolic diseases such as diabetes and obesity have become scientific research hotspots. Metabolic measurement plays an increasingly prominent role in the research on metabolic diseases such as diabetes and obesity, and integrated research on model animals has applied energy metabolism measurement to the in-depth investigation of diabetes, obesity, cardiovascular diseases, insulin tolerance and metabolic syndrome. However, most metabolic monitoring systems available on the market still rely on decades-old technologies with poor system performance and strong animal environmental stress, resulting in poor quality, vague temporal resolution, and poor repeatability of the data obtained. In this context, Sable Systems launched a small high-resolution animal metabolic and behavioral phenotyping tool to deeply study and analyze model animals' energy balance, food preference, environmental factors, and behavior. Particularly, the relevant mode of action can only be discerned from very small signals when evaluating drug efficacy and neurobiological or physiological changes. As a result, high-resolution measurement tools have become the key to the success of experiments.
Cutting-edge Technology for Measuring Energy Metabolism
Sufficient accuracy and repeatability allow more flexibility in the research scale and help obtain significant results using fewer animal groups, thereby saving the number of experiments and reducing experiment costs.
It can easily detect traces of changes in oxygen and carbon dioxide, ensuring a higher gas flow rate in metabolic cages to improve ambient conditions in the cages and optimize system performance. Higher gas flow rates can improve the accuracy and precision of measurement, significantly increase the frequency (time resolution) of effective metabolic data collection, acquire synchronously correlated metabolic data and behavioral events, and obtain energy consumption under different behavioral states such as resting energy expenditure (REE), etc.
The first-in-class pull-out airflow generation principle allows the metabolic cage to be laid with bedding without sealing, eliminating animals' need to familiarize themselves with the new environment. As shown in the figure below, animals were transferred to the metabolic cage, and their body weight increased, demonstrating a high level of environmental comfort within the cage. With high airflow rate and air exchange frequency, the metabolic cage continuously provides animals with sufficient fresh air, which is in line with relevant regulations of IACUA, ensuring that the metabolic levels of animals are measured at optimal conditions.
It maximizes system flexibility with optional accessories to meet the needs of diverse scientific experiments. These optional accessories include but are not limited to: infrared & remote measurement units for feeding monitoring, drinking monitoring, weight monitoring, running wheel monitoring and XYZ axis movement measuring, environmental control box, metabolic treadmill and high-altitude hypoxic environment simulator, etc. These accessories used by modern systems offer high-frequency synchronized data along metabolism data of O2, CO2 and water vapor.
Responsive, knowledgeable, and professional after-sales support is required for highly customizable systems to help researchers with data mining. We share the same goal with researchers to generate accurate, real data, and provide researchers with resources to maximize the utility of their systems.
Application
Modules
Promethion Core
Food Intake Monitor
Water Intake Monitor
Beam Break Activity Monitor
ESA Environmental Sensor Array
Body Mass Monitor
Access Control Door
Wheel Activity Monitor
Programmable Wheel Stop
Telemetry Module for Body Temperature and Heart Rate
Environmental Control Cabinets (Temperature, light etc.)
Promethion Isocage for Mice (Biosecurity)
Sable Metabolic Treadmill
Tecniplast metabolic cages (refrigeration)
Altitude Control Technology (ACT)
Stable Isotope Gas Analyzer (13C, 18O)
Promethion Methane Gas Analyzer
Promethion LIVE™
The Promethion Live™ software platform maximizes experiment success by verifying system performance and simplifying experiment setup. One-step gas calibration ensures accurate respirometry measurements. User selectable configuration options are system specific. Status indicators of vital components verifies system performance. Routine experiment configurations are simply saved and reused. Smart setup delivers reliable experiments so that you can proceed with confidence.
Promethion Live empowers you with real-time animal and system information needed to make key decisions at any time and any place. You’ll always know the health and welfare of each animal. By monitoring activity, ingestive behavior and weight change, you will know when to make adjustments. You have total control over your experiment through continual monitoring of all system components.
Now you can explore comparative trends during an experiment looking at every facet measured, such as running activity, food consumption, or energy expended (data shown). The experiment result is no longer a black box to be opened at the end. Promethion Live provides the mean or median of grouped data for statistical comparison in real time. The data may be presented in real time or extracted for further evaluation.
Related Products
All-around Protection
Sable Systems International is committed to designing and producing cutting-edge gas, metabolic and behavioral measurement systems for calorimetry, respirometry, metabolic/behavioral phenotyping and gas analysis. Its products enable high accuracy and resolution, efficient workflow and reliable performance, giving you confidence in results. Scientists worldwide rely on Sable's technologies to meet their research needs in physiological, biomedical, environmental, process control, and gas analysis applications. Our scientists, application engineers and customer support representative team are dedicated to understanding the nature of your work and your research goals. We can recommend instruments or configure a fully-integrated system to meet your needs. We offer a three-year warranty on our products and technical support. Founded by scientists, Sable remains in close connection to research communities and uniquely responds to experimental scientists' needs in academia and industry. By choosing Sable Systems, you will join many scientists who have used our products in remarkable discoveries and breakthroughs over the past two decades, many of which have been cited in Science, Nature, PNAS and other major journals.
Consultant
Research Professor, Department of Physical Sciences, University of Nevada
Dr. John Lighton, founder and chief scientist of Sable, is a world-renowned respiratory metabolism research expert, adjunct professor in the Department of Physiology at the University of Nevada, Las Vegas, has published nearly 100 articles on metabolism, and is the author of: Measuring Metabolic Rates: A Manual for Scientist. Oxford University Press.
Marshall McCue is a comparative physiologist with expertise in nutritional physiology and bioenergetics in humans and animal models. He has published over 60 peer reviewed papers (over 30 of which involve stable isotopes) and edited the book, Comparative Physiology of Fasting, Starvation, and Food Limitation. McCue is an associate editor for the journals Comparative Biochemistry and Physiology and Physiological and Biochemical Zoology and has been a member of the APS since 2002. In 2018 McCue joined Sable Systems International to develop a multiplexed system capable of real-time stable isotope analyses.
