High frequency small animal ultrasound system obtains non-invasive images of preclinical animals with resolution up to 30μm. An easy to operate interface with Intelligent touch screen.

Mouse probe center frequency is 40MHz, adjustable from 33MHz to 50MHz. Rat probe center frequency is 25MHz, adjustable from 15 to 25MHz.

S-Sharp Prospect T1 system provide several imaging mode, include: B mode, displays the object under examination, with the gray level representing the intensities of echo signals; M-mode, displays the motion of tissue detected by one line in B-mode over time and is commonly used in the cardiovascular related research; DP mode, Flow velocity measurements based on Doppler effects. Two modes are available (color and power Doppler), where the blood flow information is measured and color-coded; PW mode, observing flow velocity distribution as a function of time at a specific gate; TDI mode, utilizes modifications of blood flow Doppler technology and calculates velocity from frequency shifts in received ultrasound data in a similar manner; CT mode, Offers the ability to image tumor angiogenesis, inflammation, and quantification of micro-vascular structure using contrast agents; Ultrasound Guided Micro-Injection; ARF mode, provides shear wave elasticity imaging. Externally applying an acoustic radiation force induces shear wave insides the tissue. By detecting and the shear wave propagation, tissue mechanical properties such as elasticity and shear wave velocity can be calculated.

S-Sharp Prospect T1 system is a high resolution imaging system, widely used in a lot of preclinical area, include: cardiovascular research, cancer research, developmental biology research, general imaging, ophthalmic imaging, Reproductive Biology Research and so on.

• Flexible and precise positioning with displacement of 2mm per round (screw pitch) for X, Y, Z-axis, Comprehensive measurement tools for image analysis with 2-D and 3-D image data.

• Adjustable imaging parameters (center frequency, cycle, PRF, TGC, …etc) for each probe to optimize image quality in different applications.

• Intuitive tablet functions-pinch, slide or tap, even with gloves on

• Real-time color Doppler imaging and triplex imaging in update mode (B/PW/Color).

• Save static or dynamic data in multiple data formats including raw, jpg, tif, bmp, DICOM, cineloop (up to 2000 frames) and avi.

Yuma Horii, Shoichi Matsuda, Chikashi Toyota, Takumi Morinaga, Takeo Nakaya, Soken Tsuchiya, Masaki Ohmuraya, Takanori Hironaka, Ryo Yoshiki, Kotaro Kasai, Yuto Yamauchi, Noburo Takizawa, Akiomi Nagasaka, Akira Tanaka, Hidetaka Kosako and Michio Nakaya, “VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid–liquid phase separation”, Nature Communications, 14, Article number: 550, 2023.

Dashuai Zhu, Shuo Liu, Ke Huang, Junlang Li, Xuan Mei, Zhenhua Li and Ke Cheng, “Intrapericardial long non-coding RNA–Tcf21 antisense RNA inducing demethylation administration promotes cardiac repair”, European Heart Journal, 44(19), p.1748-1760, 2023.

Ai-Ho Liao, Yu-An Lee, Dao-Lung Lin, Ho-Chiao Chuang, Jehng-Kang Wang, Ching-En Chang, Hsiang-Tzu Li, Ting-Yi Wu, Cheng-Ping Shih, Chih-Hung Wang and Yueng-Hsiang Chu, “Treatment efficacy of low-dose 5-fluorouracil with ultrasound in mediating 5-fluorouracil-loaded microbubble cavitation in head and neck cancer”, Drug Delivery, 30(1), p.1-13, 2023.