Promethion Whole Room Indirect Calorimeter, based on indirect calorimetry, is a state-of-the-art tool for measuring human energy metabolism. It enables long-term monitoring of natural and unencumbered metabolic processes within a comfortable room environment. Energy metabolism can be monitored with extreme temporal resolution, ensuring precise assessment of the metabolic effects induced by various activities. Furthermore, our system can provide data on the relative utilization rates of energy substrates (such as fats or carbohydrates), resting metabolic rate, and respiratory quotient for the individual being tested.

The system comprises a monitoring workstation and a calorimeter chamber. The monitoring workstation includes a metabolic monitoring mainframe and a computer, among other components. The chamber itself is typically a comfortable apartment-style room equipped with doors, windows, a temperature control system, a bed, a bathroom, a stationary bicycle (or treadmill), and reliable safety alarm devices. It can also be customized with a computer, television, telephone, sofa, and other exercise equipment, depending on the research needs of the user. The size and layout of the calorimeter chamber can be highly customized to meet the individual needs of researchers.

Additionally, third-party monitoring devices can be installed according to the user's research requirements, such as dietary information collection systems, exercise and behavioral monitoring systems, various physiological parameter monitoring systems (body temperature, heart rate, blood pressure, and EEG, etc.), and waste sample collection systems.

Our system is widely used around the world, including at Columbia University Medical Center, St. Luke's Hospital in New York, Pennington Biomedical Research Center, University of California, Davis, and the University of Hohenheim in Germany.

SableHD™ High-Definition Technology

All Promethion systems incorporate SableHD™ high-definition technology, enabling users to collect data with resolutions ranging from 0.001 to 0.0001 or even higher. This results in clearer, more detailed, higher quality, and more reliable experimental outcomes. All critical measurements and analyses are captured and recorded more frequently and at a higher standard. With Sable's ultimate precision, you can have complete confidence in the data obtained. Users can avoid all the drawbacks associated with low-resolution analysis, such as large-scale data averaging to compensate for poor signal stability, inter-study data inconsistencies, data drift, and poor data reliability. With SableHD™ technology, your research will be done right the first time, eliminating the need for repeated experiments.

Raw Data Storage

Raw data storage means there are no secret algorithms or hidden pre-processed data; all data is transparent and fully traceable. Users can extract important parameters from their research in any way they prefer. All data information is highly synchronized with system time. No data information can truly be lost. Should users decide to re-analyze the collected data or verify it for quality control purposes, the raw data can be fully accessed in its original high-resolution state.

Water Vapor Dilution Compensation

Water vapor dilution compensation avoids the chemical dehumidification process of sample gases, significantly enhancing the accuracy of experimental results. All Promethion gas analyzers come equipped with a water vapor pressure analyzer to achieve water vapor dilution compensation. The system uses readings from the water vapor pressure analyzer, combined with data from the analyzer's atmospheric pressure sensor, to compensate for O2 and CO2 concentrations and to correct for flow in the presence of water vapor, greatly improving the precision of system measurements.

After-Sales Service

The Sable academic and technical support team will provide advice and assistance for your future applications.

Whyte, K. J., Rising, R., Albu, J. B., & Pi-Sunyer, X. (2013). Evaluation of a new whole room indirect calorimeter for measurement of resting metabolic rate. FASEB J, 27, 859.

Shechter, A., Rising, R., Albu, J. B., & St-Onge, M. P. (2013). Experimental sleep curtailment causes wake-dependent increases in 24-h energy expenditure as measured by whole-room indirect calorimetry. The American Journal of Clinical Nutrition, 98(6), 1433-1439.

Markwald, R. R., Melanson, E. L., Smith, M. R., Higgins, J., Perreault, L., Eckel, R. H., & Wright, K. P. (2013). Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain. Proceedings of the National Academy of Sciences, 110(14), 5695-5700.

Rising, R., Whyte, K., Albu, J., Pi-Sunyer, X. (2015) Evaluation of a new whole room indirect calorimeter specific for measurement of resting metabolic rate. Nutrition & Metabolism, 12(46)